CURRICULUM VITAE del Dott. PAOLO GUIDETTI

Paolo Guidetti si è laureato in Chimica e Tecnologie Farmaceutiche nel 1992 presso l’Università di Modena e Reggio Emilia discutendo una tesi sperimentale sugli effetti neurotossici del metilmercurio*.
Il giorno successivo alla sua laurea Paolo è partito per raggiungere il gruppo di lavoro del Prof. R. Schwarcz, Director for Neuroscience, Maryland, Psychiatric Research Center, Baltimora e per iniziare il suo lavoro di ricerca dedicato all’eziopatogenesi della Corea di Huntington. Negli anni successivi ha svolto attività didattica nell’Università di Modena e Reggio Emilia come professore a contratto.

Pubblicazioni:

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. Cell. 2011 Jun 10;145(6):863-74.

Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R. Neuropsychopharmacology. 2010 Jul;35(8):1734-42.

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. Sathyasaikumar KV, Stachowski EK, Amori L, Guidetti P, Muchowski PJ, Schwarcz R. J Neurochem. 2010 Jun;113(6):1416-25.

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Schwarcz R, Guidetti P, Sathyasaikumar KV, Muchowski PJ. Prog Neurobiol. 2010 Feb 9;90(2):230-45. Review.

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R. J Neurochem. 2009 Apr;109(2):316- 25.

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Amori L, Wu HQ, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R. Neuroscience. 2009 Mar 3;159(1):196-203.

Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. Lehrmann E, Guidetti P, Löve A, Williamson J, Bertram EH, Schwarcz R. Epilepsia. 2008;49 Suppl 2:13-23.

Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N- methyl-D- aspartate neurotoxicity. Poeggeler B, Rassoulpour A, Wu HQ, Guidetti P, Roberts RC, Schwarcz R. Neuroscience. 2007 Aug 10;148(1):188-97.

Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R. J Neurochem. 2007 Jul;102(1):103-11.

Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. Ceresoli-Borroni G, Guidetti P, Amori L, Pellicciari R, Schwarcz R. J Neurosci Res. 2007 Mar;85(4):845-54.

Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R. Glia. 2007 Jan 1;55(1):78-92.

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Guidetti P, Bates GP, Graham RK, Hayden MR, Leavitt BR, MacDonald ME, Slow EJ, Wheeler VC, Woodman B, Schwarcz R. Neurobiol Dis. 2006 Jul;23(1):190-7.

Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain. Ceresoli- Borroni G, Rassoulpour A, Wu HQ, Guidetti P, Schwarcz R.J Neural Transm (Vienna). 2006 Oct;113(10):1355-65.

Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease. Sapko MT, Guidetti P, Yu P, Tagle DA, Pellicciari R, Schwarcz R. Exp Neurol. 2006 Jan;197(1):31-40.

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Guidetti P, Luthi-Carter RE, Augood SJ, Schwarcz R. Neurobiol Dis. 2004 Dec;17(3):455-61. 3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease? Guidetti P, Schwarcz R. Adv Exp Med Biol. 2003;527:137-45.

Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus. Alkondon M, Pereira EF, Yu P, Arruda EZ, Almeida LE, Guidetti P, Fawcett WP, Sapko MT, Randall WR, Schwarcz R, Tagle DA, Albuquerque EX. J Neurosci. 2004 May 12;24(19):4635-48.

Determination of alpha-aminoadipic acid in brain, peripheral tissues, and body fluids using GC/MS with negative chemical ionization. Guidetti P, Schwarcz R. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):132- 9.

Kynurenate production by cultured human astrocytes. Kiss C, Ceresoli-Borroni G, Guidetti P, Zielke CL, Zielke HR, Schwarcz R. J Neural Transm (Vienna). 2003 Jan;110(1):1-14.

Cytochrome oxidase activity is increased in +/Lc Purkinje cells destined to die. Vogel MW, Fan H, Sydnor J, Guidetti P. Neuroreport. 2001 Oct 8;12(14):3039-43.

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo. Wu HQ, Guidetti P, Goodman JH, Varasi M, Ceresoli-Borroni G, Speciale C, Scharfman HE, Schwarcz R. Neuroscience. 2000;97(2):243-51.

In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate- induced neurotoxicity in the rat striatum. Guidetti P, Wu HQ, Schwarcz R. Exp Neurol. 2000 May;163(1):123-30.

Early kynurenergic impairment in Huntington's disease and in a transgenic animal model. Guidetti P, Reddy PH, Tagle DA, Schwarcz R. Neurosci Lett. 2000 Apr 14;283(3):233-5.

Modulation and function of kynurenic acid in the immature rat brain. Schwarcz R, Ceresoli- Borroni G, Wu HQ, Rassoulpour A, Poeggeler B, Hodgkins PS, Guidetti P. Adv Exp Med Biol. 1999;467:113-23.

3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. Guidetti P, Schwarcz R. Eur J Neurosci. 1999 Nov;11(11):3857-63.

Acute and chronic changes in kynurenate formation following an intrastriatal quinolinate injection in rats. Ceresoli-Borroni G, Guidetti P, Schwarcz R. J Neural Transm (Vienna). 1999;106(3-4):229- 42.

Indole-3- propionate: a potent hydroxyl radical scavenger in rat brain. Poeggeler B, Pappolla MA, Hardeland R, Rassoulpour A, Hodgkins PS, Guidetti P, Schwarcz R. Brain Res. 1999 Jan 9;815(2):382-8.

Dopaminergic control of kynurenate levels and N-methyl- D-aspartate toxicity in the developing rat striatum. Poeggeler B, Rassoulpour A, Guidetti P, Wu HQ, Schwarcz R. Dev Neurosci. 1998;20(2-3):146- 53.

Characterization of rat brain kynurenine aminotransferases I and II. Guidetti P, Okuno E, Schwarcz R. J Neurosci Res. 1997 Nov 1;50(3):457-65.

Brain-specific modulation of kynurenic acid synthesis in the rat. Gramsbergen JB, Hodgkins PS, Rassoulpour A, Turski WA, Guidetti P, Schwarcz R. J Neurochem. 1997 Jul;69(1):290-8. Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.

Ceresoli G, Guidetti P, Schwarcz R. Brain Res Dev Brain Res. 1997 May 20;100(1):73-81.

Kynurenine metabolism in the rat brain in vivo. Effect of acute excitotoxic insults. Schwarcz R, Ceresoli G, Guidetti P.

Adv Exp Med Biol. 1996;398:211-9. No abstract available. Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. Guidetti P, Eastman CL, Schwarcz R. J Neurochem. 1995 Dec;65(6):2621-32.

Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases. Jauch D, Urbańska EM, Guidetti P, Bird ED, Vonsattel JP, Whetsell WO Jr, Schwarcz R. J Neurol Sci. 1995 May;130(1):39-47.

A fluorimetric assay for the determination of anthranilic acid in biological materials. Guidetti P, Walsh JL, Schwarcz R. Anal Biochem. 1994 Jul;220(1):181-4.

Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate. Schmidt W, Guidetti P, Okuno E, Schwarcz R. Neuroscience. 1993 Jul;55(1):177-84.

* Prenatal exposure of rats to methylmercury: increase sensitivity of the GABA-Benzodiazepine receptor functions. P Guidetti, A Giacobazzi, P Zanoli, M Baraldi In: Metal compound in environment and life E Merian and W Haerdi Eds, Science Reviews, USA, pp 365-37, 1992